USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: Q9Y490 USC-OGP 2-DE database:  Q9Y490 Q9Y490 General information about the entry View entry in simple text format Entry name TLN1_HUMAN Primary accession number Q9Y490 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Talin-1;. Gene name Name=TLN1 Synonyms=KIAA1027, TLN Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0038: pI=4.86; Mw=62526 SPOT OGP-0077: pI=4.83; Mw=49176 SPOT OGP-0080: pI=4.81; Mw=47178 SPOT OGP-0081: pI=4.73; Mw=46386 SPOT OGP-0087: pI=4.95; Mw=43453 SPOT OGP-0090: pI=5.03; Mw=43139 SPOT OGP-0092: pI=4.95; Mw=42723 SPOT OGP-0093: pI=5.02; Mw=42512 SPOT OGP-0118: pI=5.01; Mw=36607 SPOT OGP-0122: pI=4.80; Mw=36055 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0648: pI=5.75; Mw=60192 PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-0923: pI=8.15; Mw=46247 SPOT OGP-0924: pI=8.23; Mw=46247 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1105: pI=5.51; Mw=115893 Cross-references UniProtKB/Swiss-Prot Q9Y490; TLN1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name TLN1_HUMAN Primary accession number Q9Y490 Secondary accession number(s) A6NMY0 Q86YD0 Q9NZQ2 Q9UHH8 Q9UPX3 Sequence was last modified on  November 8, 2005 (version 3) Annotations were last modified on  March 15, 2017 (version 177) Name and origin of the protein Description RecName: Full=Talin-1; Gene name Name=TLN1 Synonyms=KIAA1027, TLN Encoded on Name=TLN1; Synonyms=KIAA1027, TLN Keywords 3D-structure; Acetylation; Cell junction; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Host-virus interaction; Membrane; Phosphoprotein; Polymorphism; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL AF078828; AAD13152.1; -; mRNA EMBL AF177198; AAF23322.1; -; mRNA EMBL AF178534; AAF27330.1; -; Genomic_DNA EMBL AF178081; AAF27330.1; JOINED; Genomic_DNA EMBL AB028950; BAA82979.2; ALT_INIT; mRNA EMBL AL133410; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471071; EAW58352.1; -; Genomic_DNA EMBL BC042923; AAH42923.1; -; mRNA CCDS CCDS35009.1; -; . RefSeq NP_006280.3; NM_006289.3; . UniGene Hs.471014; -; . PDB 1SYQ; X-ray; 2.42 A; B=607-631 PDB 2MWN; NMR; -; B=308-400 PDB 4DJ9; X-ray; 2.25 A; B=2075-2103 PDBsum 1SYQ; -; . PDBsum 2MWN; -; . PDBsum 4DJ9; -; . ProteinModelPortal Q9Y490; -; . SMR Q9Y490; -; . BioGrid 112949; 70; . IntAct Q9Y490; 23; . MINT MINT-5002070; -; . STRING 9606.ENSP00000316029; -; . iPTMnet Q9Y490; -; . PhosphoSitePlus Q9Y490; -; . SwissPalm Q9Y490; -; . BioMuta TLN1; -; . DMDM 81175200; -; . OGP Q9Y490; -; . EPD Q9Y490; -; . MaxQB Q9Y490; -; . PaxDb Q9Y490; -; . PeptideAtlas Q9Y490; -; . PRIDE Q9Y490; -; . Ensembl ENST00000314888; ENSP00000316029; ENSG00000137076; . GeneID 7094; -; . KEGG hsa:7094; -; . UCSC uc003zxt.3; human; . CTD 7094; -; . DisGeNET 7094; -; . GeneCards MIR6852; -; . GeneCards TLN1; -; . HGNC HGNC:11845; TLN1; . HPA CAB002006; -; . HPA HPA004748; -; . MIM 186745; gene; . neXtProt NX_Q9Y490; -; . OpenTargets ENSG00000137076; -; . PharmGKB PA36547; -; . eggNOG KOG4261; Eukaryota; . eggNOG ENOG410XQ0V; LUCA; . GeneTree ENSGT00550000074542; -; . HOGENOM HOG000006734; -; . HOVERGEN HBG023870; -; . InParanoid Q9Y490; -; . KO K06271; -; . OMA EHVLVII; -; . OrthoDB EOG091G0644; -; . PhylomeDB Q9Y490; -; . TreeFam TF314677; -; . Reactome R-HSA-114608; Platelet degranulation; . Reactome R-HSA-354192; Integrin alphaIIb beta3 signaling; . Reactome R-HSA-354194; GRB2:SOS provides linkage to MAPK signaling for Integrins; . Reactome R-HSA-372708; p130Cas linkage to MAPK signaling for integrins; . Reactome R-HSA-381038; XBP1(S) activates chaperone genes; . Reactome R-HSA-399955; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; . Reactome R-HSA-445355; Smooth Muscle Contraction; . Reactome R-HSA-5674135; MAP2K and MAPK activation; . Reactome R-HSA-6802946; Signaling by moderate kinase activity BRAF mutants; . Reactome R-HSA-6802948; Signaling by high-kinase activity BRAF mutants; . Reactome R-HSA-6802949; Signaling by RAS mutants; . Reactome R-HSA-6802952; Signaling by BRAF and RAF fusions; . Reactome R-HSA-6802955; Paradoxical activation of RAF signaling by kinase inactive BRAF; . SIGNOR Q9Y490; -; . ChiTaRS TLN1; human; . EvolutionaryTrace Q9Y490; -; . GeneWiki TLN1; -; . GenomeRNAi 7094; -; . PRO PR:Q9Y490; -; . Proteomes UP000005640; Chromosome 9; . Bgee ENSG00000137076; -; . CleanEx HS_TLN1; -; . Genevisible Q9Y490; HS; . GO GO:0009986; C:cell surface; IEA:UniProtKB-SubCell; . GO GO:0005911; C:cell-cell junction; IC:UniProtKB; . GO GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0001726; C:ruffle; ISS:HGNC; . GO GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell; . GO GO:0045296; F:cadherin binding; IDA:BHF-UCL; . GO GO:0005178; F:integrin binding; IPI:UniProtKB; . GO GO:0030274; F:LIM domain binding; IPI:UniProtKB; . GO GO:0005200; F:structural constituent of cytoskeleton; NAS:UniProtKB; . GO GO:0017166; F:vinculin binding; IPI:UniProtKB; . GO GO:0007043; P:cell-cell junction assembly; TAS:UniProtKB; . GO GO:0007044; P:cell-substrate junction assembly; IEA:Ensembl; . GO GO:0030866; P:cortical actin cytoskeleton organization; IEA:Ensembl; . GO GO:0007016; P:cytoskeletal anchoring at plasma membrane; NAS:UniProtKB; . GO GO:0036498; P:IRE1-mediated unfolded protein response; TAS:Reactome; . GO GO:0006928; P:movement of cell or subcellular component; NAS:UniProtKB; . GO GO:0006936; P:muscle contraction; TAS:Reactome; . GO GO:0070527; P:platelet aggregation; IMP:UniProtKB; . GO GO:0002576; P:platelet degranulation; TAS:Reactome; . GO GO:0016032; P:viral process; IEA:UniProtKB-KW; . Gene3D 1.20.1410.10; -; 3; . Gene3D 1.20.1420.10; -; 1; . Gene3D 1.20.80.10; -; 1; . Gene3D 2.30.29.30; -; 1; . InterPro IPR019749; Band_41_domain; . InterPro IPR014352; FERM/acyl-CoA-bd_prot_3-hlx; . InterPro IPR019748; FERM_central; . InterPro IPR019747; FERM_CS; . InterPro IPR000299; FERM_domain; . InterPro IPR032425; FERM_f0; . InterPro IPR018979; FERM_N; . InterPro IPR002558; ILWEQ_dom; . InterPro IPR011993; PH_dom-like; . InterPro IPR015710; Talin-1; . InterPro IPR015224; Talin_cent; . InterPro IPR029071; Ubiquitin-rel_dom; . InterPro IPR015009; Vinculin-bd_dom; . InterPro IPR006077; Vinculin/catenin; . PANTHER PTHR19981:SF24; PTHR19981:SF24; 1; . Pfam PF16511; FERM_f0; 1; . Pfam PF00373; FERM_M; 1; . Pfam PF09379; FERM_N; 1; . Pfam PF01608; I_LWEQ; 1; . Pfam PF09141; Talin_middle; 1; . Pfam PF08913; VBS; 1; . ProDom PD011820; ILWEQ; 1; . SMART SM00295; B41; 1; . SMART SM00307; ILWEQ; 1; . SUPFAM SSF109880; SSF109880; 1; . SUPFAM SSF109885; SSF109885; 4; . SUPFAM SSF47031; SSF47031; 1; . SUPFAM SSF47220; SSF47220; 5; . SUPFAM SSF50729; SSF50729; 1; . SUPFAM SSF54236; SSF54236; 1; . PROSITE PS00660; FERM_1; 1; . PROSITE PS00661; FERM_2; 1; . PROSITE PS50057; FERM_3; 1; . PROSITE PS50945; I_LWEQ; 1; .

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• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
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• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
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